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At Fluxion, we’re passionate about delivering cell-based solutions that facilitate the transformation of research discoveries into new ways to diagnose and treat patients. By characterizing molecular and cellular mechanisms of disease, Fluxion’s platforms help bridge the translational medicine gap, enabling rapid advances in disease research, drug discovery, and the development of diagnostic tests.

Sodium Channels 

Responsible for the rise of the action potential in neurons and cardiac muscle, sodium channels are important targets for drug research. Inhibitory drug interactions are investigated in safety pharmacology, pain research, and naturally-occurring toxin research. Although automated patch clamp systems have successfully studied sodium channels, many complicated assays stay elusive.

IonFlux Mercury can act as the missing link between HTS systems and the flexibility of manual patch clamp. Sodium channel IonFlux assays benefit from:

  • Continuously flowing solutions prolong assay stability

  • Short additions followed by controlled continuous wash of drugs provide direct calculation of binding kinetics

  • Precise temperature control provides physiological conditions for drug interactions

Nav+1.8+Lido

Nav 1.8 Lidocaine dose response

 

Nav+1.7+Lido

Nav 1.7 lidocaine dose response

Nav1.7+Single-1

Gigaseal single cell recordings of Nav 1.7

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