Responsible for the rise of the action potential in neurons and cardiac muscle, sodium channels are important targets for drug research. Inhibitory drug interactions are investigated in safety pharmacology, pain research, and naturally-occurring toxin research. Although automated patch clamp systems have successfully studied sodium channels, many complicated assays stay elusive.
IonFlux Mercury can act as the missing link between HTS systems and the flexibility of manual patch clamp. Sodium channel IonFlux assays benefit from:
Continuously flowing solutions prolong assay stability
Short additions followed by controlled continuous wash of drugs provide direct calculation of binding kinetics
Precise temperature control provides physiological conditions for drug interactions
Nav 1.8 Lidocaine dose response
Nav 1.7 lidocaine dose response
Gigaseal single cell recordings of Nav 1.7