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At Fluxion, we’re passionate about delivering cell-based and cell-free solutions that facilitate the transformation of research discoveries into new ways to diagnose and treat patients. By characterizing molecular and cellular mechanisms of disease, Fluxion’s platforms help bridge the translational medicine gap, enabling rapid advances in disease research, drug discovery, and the development of diagnostic tests.

Automated Patch Clamp

IonFlux Mercury ULTRA

ULTRA high throughput automated patch clamp array for advanced assays

The highest throughput continuous flow APC system on the market

 

IonFlux Mercury Ultra is the latest iteration of the industry-leading IonFlux platform, with enhancements in every aspect of the technology. With 256 independent amplifiers capable of non-stop recordings, and an uninterrupted sweep length of up to 300 seconds, IonFlux Mercury Ultra extends the IonFlux system’s industry-leading capabilities in compound delivery, rapid solution exchange, and assay flexibility. Now, the most complicated ligand-gated and demanding voltage-gated assays can run in parallel, decreasing experiment time and accelerating completion of projects.
 
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Mercury ULTRA No Background

 

Features

128/256 independent recordings

64/128 parallel & independent experiments.

SBS Standard 384 well Plates. >500 data points per plate

Flexible synchronous and asynchronous assays

Continuous flow of solutions and compounds with integrated wash steps for maximum assay stability

In-plate fast solution exchange without the need for compound pipette stacking

Single cell giga-ohm seal recordings and
ensemble recordings (20 cells) with no artificial averaging

Integrated temperature control (ambient to
40 degrees). 

Independent cell source for multiple cell types screening at the same time (up to 64/128)

Centralized operation and integrated software for assay development and analysis

Compatibility with XLFit templates for automatic IC/EC50 reporting

Included automated liquid handling robot for plate preparation and compound dilution (Mercury Automate)

 

10,000 Data points per hour

Application SPOTLIGHT

Screening positive allosteric modulators for NMDA Receptors

NMDAR hypofunction is implicated in the pathophysiology of schizophrenia. Positive allosteric modulators (PAMs) are molecules capable of enhancing a receptor's signal. In a recent study, IonFlux HT technology was used in a screening pipeline to identify GluN2A selective NMDAR PAMs. 

READ ARTICLE (Mathew Volgraf et al)
Application Spotlight

Identifying potential analgesic candidates

Glycine receptors play a key role in mediating inhibitory neurotransmission and hence contribute to the regulation of pain signaling in the dorsal horn. This recent study used IonFlux HT technology to identify positive allosteric modulators for GlyRα3.

READ ARTICLE (Clara Stead et al)

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Contact us for more information about IonFlux systems. 

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