Automated Patch Clamp
IonFlux Mercury ULTRA
ULTRA high throughput automated patch clamp array for advanced assays
The highest throughput continuous flow APC system on the market
128/256 independent recordings
64/128 parallel & independent experiments.
SBS Standard 384 well Plates. >500 data points per plate
Flexible synchronous and asynchronous assays
Continuous flow of solutions and compounds with integrated wash steps for maximum assay stability
In-plate fast solution exchange without the need for compound pipette stacking
Single cell giga-ohm seal recordings and
ensemble recordings (20 cells) with no artificial averaging
Integrated temperature control (ambient to
Independent cell source for multiple cell types screening at the same time (up to 64/128)
Centralized operation and integrated software for assay development and analysis
Compatibility with XLFit templates for automatic IC/EC50 reporting
Included automated liquid handling robot for plate preparation and compound dilution (Mercury Automate)
10,000 Data points per hour
Screening positive allosteric modulators for NMDA Receptors
NMDAR hypofunction is implicated in the pathophysiology of schizophrenia. Positive allosteric modulators (PAMs) are molecules capable of enhancing a receptor's signal. In a recent study, IonFlux HT technology was used in a screening pipeline to identify GluN2A selective NMDAR PAMs.
Identifying potential analgesic candidates
Glycine receptors play a key role in mediating inhibitory neurotransmission and hence contribute to the regulation of pain signaling in the dorsal horn. This recent study used IonFlux HT technology to identify positive allosteric modulators for GlyRα3.