IonFlux uses a unique plate design that allows for all fluid activity to be conducted within the recording plate proper. Using flexible and user controlled pneumatic system, IonFlux provides high speed liquid exchange, continuous solution flow, and drug delivery without the use of an external liquid handler. The in-plate movement of solutions cancels typical ion channel assays problems such as stacking related drug cross contamination. The continuous flow system alleviates assays with slow acting or sticky compounds.
IonFlux plate design on the cover of Assay and Drug Development in 2012
IonFlux plates come in two different standard designs, 96 well plates for use with all lonFlux system having 16 amplifiers and 384 well plates for use with all lonFlux systems with 64 amplifiers or more.
IonFlux plates come in two different cell trapping and recording designs:
- Single Cells: Using whole cell patch clamp technique and achieving Giga-Ω seal recordings, lonFlux single cell plates are perfect for specialized assays requiring complete voltage/current control of an independent cell, mimicking manual patch clamp conditions while providing automated systems flexibility.
- Ensemble cells: Just like single cell plates, ensemble plates also use whole cell patch clamp techniques but now with 20 cells in parallel, setting a standard for consistency and throughput.
